Maritime Spare Parts Management: Current State-of-the-Art

Having the right spare part at the right time to the right place for ship maintenance to the minimal possible costs is an exigent management problem that maritime shipping companies face. This is especially challenging in bulk shipping where routes are not fixed, but subsequent port calls depend on spot market dynamics. Thus, spare parts allocation ahead in time is limited, but possible if failures rates of ship components and their timing can be foreseen, so that spare parts can be allocated to hedge against the risk of long waiting times and thus ship downtimes. Thus, monitoring the condition of components key to the ships performance is essential to the task. This can enable companies to significantly reduce operational costs of their fleet leading to a competitive advantage in a highly volatile market regarding demand and demand-driven freight rates. However, shipping companies seem far away from applying such methods due to various challenges ranging from data gathering and cultivating an understanding of data quality needs, adaptation to move from preventive towards predictive and condition-based monitoring, and the introduction and application of decision support tools for sourcing, spare parts allocation, and inventory management. In this paper, we investigate the current state of the art of maintenance and related spare parts logistics management for maritime shipping and discuss the application of methods to the bulk carriage market. We add practical knowledge from case companies and discuss how challenges can be overcome in providing guidelines for companies

Structural and Functional Dependence of Objects in Data Bases

Let the information of a civil engineering application be decomposed into objects of a given set of classes. Then the set of objects forms the data base of the application. The objects contain attributes and methods. Properties of the objects are stored in the attributes. Algorithms which the objects perform are implemented in the methods of the objects. If objects are modified by a user, the consistency of data in the base is destroyed. The data base must be modified in an update to restore its consistency. The sequence of the update operations is not arbitrary, but is governed by dependence between the objects. The situation can be described mathematically with graph theory. The available algorithms for the determination of the update sequence are not suitable when the data base is large. A new update algorithm for large data bases has been developed and is presented in this paper

Introduction to Intelligent Decision Support and Big Data for Logistics and Supply Chain Management Minitrack

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Structural and Functional Dependence of Objects in Data Bases

Let the information of a civil engineering application be decomposed into objects of a given set of classes. Then the set of objects forms the data base of the application. The objects contain attributes and methods. Properties of the objects are stored in the attributes. Algorithms which the objects perform are implemented in the methods of the objects. If objects are modified by a user, the consistency of data in the base is destroyed. The data base must be modified in an update to restore its consistency. The sequence of the update operations is not arbitrary, but is governed by dependence between the objects. The situation can be described mathematically with graph theory. The available algorithms for the determination of the update sequence are not suitable when the data base is large. A new update algorithm for large data bases has been developed and is presented in this paper

Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G4C2 insertion length is variable, and patients can carry up to several thousand repeats. Dipeptide repeat proteins (DPRs) translated from G4C2 transcripts are thought to be a main driver of toxicity. Experiments in model organisms with relatively short DPRs have shown that arginine-rich DPRs are most toxic, while polyGlycine–Alanine (GA) DPRs cause only mild toxicity. However, GA is the most abundant DPR in patient brains, and experimental work in animals has generally relied on the use of low numbers of repeats, with DPRs often tagged for in vivo tracking. Whether repeat length or tagging affect the toxicity of GA has not been systematically assessed. Therefore, we generated Drosophila fly lines expressing GA100, GA200 or GA400 specifically in adult neurons. Consistent with previous studies, expression of GA100 and GA200 caused only mild toxicity. In contrast, neuronal expression of GA400 drastically reduced climbing ability and survival of flies, indicating that long GA DPRs can be highly toxic in vivo. This toxicity could be abolished by tagging GA400. Proteomics analysis of fly brains showed a repeat-length-dependent modulation of the brain proteome, with GA400 causing earlier and stronger changes than shorter GA proteins. PolyGA expression up-regulated proteins involved in ER to Golgi trafficking, and down-regulated proteins involved in insulin signalling. Experimental down-regulation of Tango1, a highly conserved regulator of ER-to Golgi transport, partially rescued GA400 toxicity, suggesting that misregulation of this process contributes to polyGA toxicity. Experimentally increasing insulin signaling also rescued GA toxicity. In summary, our data show that long polyGA proteins can be highly toxic in vivo, and that they may therefore contribute to ALS/FTD pathogenesis in patients

Feeling Political

Historicizing both emotions and politics, this open access book argues that the historical work of emotion is most clearly understood in terms of the dynamics of institutionalization. This is shown in twelve case studies that focus on decisive moments in European and US history from 1800 until today. Each case study clarifies how emotions were central to people’s political engagement and its effects. The sources range from parliamentary buildings and social movements, to images and speeches of presidents, from fascist cemeteries to the International Criminal Court. Both the timeframe and the geographical focus have been chosen to highlight the increasingly participatory character of nineteenth- and twentieth-century politics, which is inconceivable without the work of emotions

Resilient Organizations in the Third Sector. Professionalized Membership Associations, Social Enterprises, Modern Hybrids

How do nonprofit organizations manage to survive? How are they able to adapt to changed environments without losing their distinctiveness? Fifteen case studies of nonprofit organizations operating across Europe tell us a story of how to make ends meet. The cases presented, identified and analyzed in the framework of the European Union-funded research project Third Sector Impact (TSI) (Enjolras et al. 2018)1 , are organizations that are confronted with an increasingly hostile environment in terms of the availability of resources and co-operation with government. Some of them, particularly those in Southern Europe and in the U.K., suffer from austerity politics and financial cutbacks; some are struggling for recognition on the part of the general public or the government. This is still the case especially in post-socialist countries. The goal of this e-book is to highlight that, despite the fact that third sector organizations (TSOs) are currently confronted with a thoroughly changed environment, they continue contributing to the well-being of citizens in Europe through their innovativeness and by providing services as well as avenues for active participation. The book focuses on case studies of organizations that managed to find a way to adapt to a significantly changed organizational environment by alluding to the power of resilience.How do nonprofit organizations manage to survive? How are they able to adapt to changed environments without losing their distinctiveness? Fifteen case studies of nonprofit organizations operating across Europe tell us a story of how to make ends meet. The cases presented, identified and analyzed in the framework of the European Union-funded research project Third Sector Impact (TSI) (Enjolras et al. 2018)1 , are organizations that are confronted with an increasingly hostile environment in terms of the availability of resources and co-operation with government. Some of them, particularly those in Southern Europe and in the U.K., suffer from austerity politics and financial cutbacks; some are struggling for recognition on the part of the general public or the government. This is still the case especially in post-socialist countries. The goal of this e-book is to highlight that, despite the fact that third sector organizations (TSOs) are currently confronted with a thoroughly changed environment, they continue contributing to the well-being of citizens in Europe through their innovativeness and by providing services as well as avenues for active participation. The book focuses on case studies of organizations that managed to find a way to adapt to a significantly changed organizational environment by alluding to the power of resilience